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KMID : 0383819620090010074
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Tuberculosis and Respiratory Diseases
1962 Volume.9 No. 1 p.74 ~ p.81
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The Sensitivity Testing to 1,000 Strains of Mycobacterium tuberculosis were isolated from 1,140 Korean patients.
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박승함(朴承咸)/Park Seung Hahm
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Abstract
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Following results were obtained the Sensitivity Testing to 1,000 strains of M.
tuberculosis were isolated from 1,140 Korean patients, out and in, at National Medical
Center from Jan. 1960 to Oct.1961. Twelve Lwenstein-Jensen media were used which
consist of PAS 10γ, 1γ, INH 50γ, 10γ, 1γ, 0.1γ, and SM 100γ, 50γ, 10γ, 3γ, per
ml of concentration and two controls for each examination. After 6 weeks incubation,
final reading was performed. The definition of resistance was growth in PAS 10γ, INH
1γ and SM 10γ per ㎖ of concentration.
1) Resistant to single drug was most common, it was found in 227 cases(ca. 28%)
2) Resistant to two drug was found in 232 cases (23%) and resistant to three drug in
223 cases(22%)
3) Isoniazid resistant was most common and it was found in 601 cases(60%).
Streptomycin resistant was found in 415 cases (ca. 42%) and it was almost equalled by
PAS resistance 39 cases (ca. 40%).
4) There was difference of resistance between both sexes.
5) There was found in 15 cases resistant to three drugs among whom did not receive
any Chemotherapy.
6) Most susceptibility was found in urine specimens which 28 cases(54%) were
sensitive and 3 cases (6%) resistant to three drugs among total 52 urine specimens
compared with the other specimens, especially, 205 cases(25%) were sensitive and 197
cases(24%) resistant to three drugs among total 834 sputum specimens.
7) There were some differences in the percentage of susceptibility according to the
age group. The group of 10∼19 age showed the lowest resistant rate (16%) to three
drugs and 30∼39 age group showed the lowest sensitive rate(17%) and the highest
resistant rate(25%) to three drugs.
8) 186 cases include both without any chemotherapy and with regular chemotherapy
within 6 months belonged to sensitive to three drugs occupied about 70% among total
268 cases sensitive to three drugs.
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